Drug interactions
Colchicine + Teclistamab
Severity: Moderate
Colchicine and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab causes cytokine release that can transiently suppress CYP450 enzymes including CYP3A4. This may raise colchicine concentrations and the risk of dose-related toxicity, particularly around step-up dosing and CRS episodes.
What this interaction means in plain words
Colchicine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Teclistamab belongs to Oncology.
Why it happens
Cytokine release suppresses CYP3A4 activity, reducing colchicine clearance.
What to do
Monitor for colchicine toxicity (GI symptoms, myopathy, cytopenias) during the period of CRS risk after teclistamab initiation. Reduce the colchicine dose if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
- Ethosuximide + Teclistamab Moderate
Frequently asked questions
Can I take Colchicine with Teclistamab?
MediHelp rates the interaction as moderate. Colchicine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab causes cytokine release that can transiently suppress CYP450 enzymes including CYP3A4. This may raise colchicine concentrations and the risk of dose-related toxicity, particularly around step-up dosing and CRS episodes.
How serious is the interaction between Colchicine and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity (GI symptoms, myopathy, cytopenias) during the period of CRS risk after teclistamab initiation. Reduce the colchicine dose if toxicity is suspected.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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