Drug interactions
Ergotamine + Teclistamab
Severity: Moderate
Ergotamine and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release caused by teclistamab can transiently suppress CYP enzymes, which may raise ergotamine concentrations. Elevated levels risk vasospasm and ischemia.
What this interaction means in plain words
Ergotamine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces ergotamine metabolism.
What to do
Monitor for ergotism signs around step-up doses and during cytokine release syndrome. Consider withholding ergotamine during those periods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Teclistamab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ethosuximide + Teclistamab Moderate
Frequently asked questions
Can I take Ergotamine with Teclistamab?
MediHelp rates the interaction as moderate. Ergotamine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release caused by teclistamab can transiently suppress CYP enzymes, which may raise ergotamine concentrations. Elevated levels risk vasospasm and ischemia.
How serious is the interaction between Ergotamine and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism signs around step-up doses and during cytokine release syndrome. Consider withholding ergotamine during those periods.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
