Drug interactions
Pimozide + Teclistamab
Severity: Major
Pimozide and Teclistamab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab-induced cytokine release can transiently suppress CYP450 activity, raising levels of CYP3A4 substrates such as pimozide. Higher pimozide exposure increases the risk of QT prolongation and ventricular arrhythmia.
What this interaction means in plain words
Pimozide and Teclistamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Teclistamab belongs to Oncology.
Why it happens
Cytokine release suppresses CYP3A4 expression and activity, reducing pimozide clearance.
What to do
Avoid pimozide around teclistamab step-up dosing and during cytokine release syndrome if an alternative exists. Otherwise monitor ECG and for pimozide toxicity and lower the dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Teclistamab
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
- Ethosuximide + Teclistamab Moderate
Frequently asked questions
Can I take Pimozide with Teclistamab?
MediHelp rates the interaction as major. Pimozide and Teclistamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Teclistamab-induced cytokine release can transiently suppress CYP450 activity, raising levels of CYP3A4 substrates such as pimozide. Higher pimozide exposure increases the risk of QT prolongation and ventricular arrhythmia.
How serious is the interaction between Pimozide and Teclistamab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pimozide around teclistamab step-up dosing and during cytokine release syndrome if an alternative exists. Otherwise monitor ECG and for pimozide toxicity and lower the dose as needed.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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