Drug interactions
Ethotoin + Metoclopramide
Severity: Moderate
Ethotoin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so combined use may add to CNS effects. Metoclopramide can also lower seizure threshold in susceptible patients, which is relevant to patients on anticonvulsants.
What this interaction means in plain words
Ethotoin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; metoclopramide may reduce seizure control in epilepsy.
What to do
Monitor for sedation and for any change in seizure frequency. Use the lowest effective metoclopramide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Ethotoin with Metoclopramide?
MediHelp rates the interaction as moderate. Ethotoin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so combined use may add to CNS effects. Metoclopramide can also lower seizure threshold in susceptible patients, which is relevant to patients on anticonvulsants.
How serious is the interaction between Ethotoin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any change in seizure frequency. Use the lowest effective metoclopramide dose.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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