Drug interactions
Ethotoin + Posaconazole
Severity: Moderate
Ethotoin and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydantoin anticonvulsants such as phenytoin lower posaconazole concentrations, and ethotoin may do so to a lesser degree. Reduced posaconazole exposure could lead to antifungal treatment failure.
What this interaction means in plain words
Ethotoin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable induction of posaconazole elimination (UDP-glucuronidation and P-gp), inferred from related hydantoins.
What to do
Avoid the combination where possible, unless the benefit outweighs the risk. If used together, monitor posaconazole trough concentrations and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ethotoin with Posaconazole?
MediHelp rates the interaction as moderate. Ethotoin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydantoin anticonvulsants such as phenytoin lower posaconazole concentrations, and ethotoin may do so to a lesser degree. Reduced posaconazole exposure could lead to antifungal treatment failure.
How serious is the interaction between Ethotoin and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, unless the benefit outweighs the risk. If used together, monitor posaconazole trough concentrations and clinical response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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