Drug interactions
Ethotoin + Ticlopidine
Severity: Moderate
Ethotoin and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19 and may reduce hydantoin metabolism, as seen with phenytoin, where toxicity has been reported. Ethotoin could accumulate, causing dizziness, ataxia and sedation.
What this interaction means in plain words
Ethotoin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ticlopidine inhibits CYP2C19 (and possibly CYP2C9), reducing ethotoin clearance.
What to do
Monitor for signs of hydantoin toxicity such as ataxia and nystagmus, and reduce the ethotoin dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Ethotoin with Ticlopidine?
MediHelp rates the interaction as moderate. Ethotoin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19 and may reduce hydantoin metabolism, as seen with phenytoin, where toxicity has been reported. Ethotoin could accumulate, causing dizziness, ataxia and sedation.
How serious is the interaction between Ethotoin and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hydantoin toxicity such as ataxia and nystagmus, and reduce the ethotoin dose if they occur.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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