Drug interactions
Etodolac + Fluvoxamine
Severity: Moderate
Etodolac and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine together with etodolac raises the risk of gastrointestinal and other bleeding beyond that of either drug alone. Risk is higher in older adults and those with ulcer history.
What this interaction means in plain words
Etodolac and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Fluvoxamine belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID platelet inhibition and mucosal injury.
What to do
Prefer a non-NSAID analgesic such as paracetamol where possible, or add a proton pump inhibitor if the combination is needed. Monitor for signs of bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Etodolac with Fluvoxamine?
MediHelp rates the interaction as moderate. Etodolac and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine together with etodolac raises the risk of gastrointestinal and other bleeding beyond that of either drug alone. Risk is higher in older adults and those with ulcer history.
How serious is the interaction between Etodolac and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol where possible, or add a proton pump inhibitor if the combination is needed. Monitor for signs of bleeding and anemia.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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