Drug interactions
Etodolac + Fondaparinux
Severity: Major
Etodolac and Fondaparinux: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac inhibits platelet function and can injure the gastric mucosa, while fondaparinux inhibits factor Xa. Taken together they raise the chance of clinically important gastrointestinal and other bleeding.
What this interaction means in plain words
Etodolac and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: NSAID-induced platelet inhibition and mucosal injury combined with factor Xa inhibition.
What to do
Avoid the combination when possible; if it is necessary, use the lowest effective NSAID dose for the shortest time and monitor for bleeding and hemoglobin changes. Consider gastroprotection and use paracetamol as an alternative analgesic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Etodolac with Fondaparinux?
MediHelp rates the interaction as major. Etodolac and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac inhibits platelet function and can injure the gastric mucosa, while fondaparinux inhibits factor Xa. Taken together they raise the chance of clinically important gastrointestinal and other bleeding.
How serious is the interaction between Etodolac and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if it is necessary, use the lowest effective NSAID dose for the shortest time and monitor for bleeding and hemoglobin changes. Consider gastroprotection and use paracetamol as an alternative analgesic.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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