Drug interactions
Etodolac + Gemifloxacin
Severity: Moderate
Etodolac and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect in susceptible patients. The risk is greatest with high doses, renal impairment or a history of seizures.
What this interaction means in plain words
Etodolac and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones inhibit GABA-A receptor binding, and NSAIDs are thought to potentiate this effect; the mechanism is not fully established.
What to do
Avoid the combination in patients with epilepsy or other seizure risk factors, and keep fluoroquinolone doses appropriate to renal function. Monitor for CNS excitation, and stop the fluoroquinolone if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Etodolac with Gemifloxacin?
MediHelp rates the interaction as moderate. Etodolac and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect in susceptible patients. The risk is greatest with high doses, renal impairment or a history of seizures.
How serious is the interaction between Etodolac and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy or other seizure risk factors, and keep fluoroquinolone doses appropriate to renal function. Monitor for CNS excitation, and stop the fluoroquinolone if seizures occur.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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