Drug interactions
Etodolac + Losartan
Severity: Major
Etodolac and Losartan: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce the antihypertensive effect of losartan and can cause acute kidney injury and hyperkalemia, particularly in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Etodolac and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAIDs block prostaglandin-mediated afferent arteriolar dilation while ARBs dilate the efferent arteriole, lowering glomerular filtration, and both can raise potassium.
What to do
Avoid or limit NSAID use in at-risk patients; otherwise monitor blood pressure, serum creatinine and potassium and ensure hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Etodolac with Losartan?
MediHelp rates the interaction as major. Etodolac and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce the antihypertensive effect of losartan and can cause acute kidney injury and hyperkalemia, particularly in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Etodolac and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit NSAID use in at-risk patients; otherwise monitor blood pressure, serum creatinine and potassium and ensure hydration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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