Drug interactions
Etodolac + Metoprolol
Severity: Moderate
Etodolac and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the blood-pressure lowering effect of metoprolol, especially with regular use over more than a week. This may lead to loss of blood pressure control.
What this interaction means in plain words
Etodolac and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Metoprolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention counteract the antihypertensive effect of the beta blocker.
What to do
Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive therapy if needed. Prefer a short NSAID course or a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Etodolac with Metoprolol?
MediHelp rates the interaction as moderate. Etodolac and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the blood-pressure lowering effect of metoprolol, especially with regular use over more than a week. This may lead to loss of blood pressure control.
How serious is the interaction between Etodolac and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive therapy if needed. Prefer a short NSAID course or a non-NSAID analgesic such as paracetamol.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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