Drug interactions
Etodolac + Rivaroxaban
Severity: Major
Etodolac and Rivaroxaban: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs increase the risk of bleeding when taken with rivaroxaban, including serious gastrointestinal hemorrhage. The risk arises from both platelet inhibition and mucosal injury on top of anticoagulation.
What this interaction means in plain words
Etodolac and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Rivaroxaban belongs to Cardiovascular.
Why it happens
Pharmacodynamic additive effect of NSAID antiplatelet action and gastric mucosal injury with factor Xa inhibition.
What to do
Avoid the combination where possible and use paracetamol for analgesia. If an NSAID is unavoidable, use the lowest dose briefly, add gastroprotection and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Etodolac with Rivaroxaban?
MediHelp rates the interaction as major. Etodolac and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs increase the risk of bleeding when taken with rivaroxaban, including serious gastrointestinal hemorrhage. The risk arises from both platelet inhibition and mucosal injury on top of anticoagulation.
How serious is the interaction between Etodolac and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for analgesia. If an NSAID is unavoidable, use the lowest dose briefly, add gastroprotection and monitor for bleeding and hemoglobin.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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