Drug interactions
Etomidate + Loxapine
Severity: Moderate
Etomidate and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a general anesthetic induction agent, and loxapine's sedative and hypotensive properties can add to its effects. This may deepen sedation and increase cardiovascular depression perioperatively.
What this interaction means in plain words
Etomidate and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from GABA-A potentiation and antipsychotic alpha blockade and sedation.
What to do
Inform the anesthesia team of loxapine use and titrate etomidate to effect. Monitor blood pressure and airway closely during induction and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Loxapine?
MediHelp rates the interaction as moderate. Etomidate and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is a general anesthetic induction agent, and loxapine's sedative and hypotensive properties can add to its effects. This may deepen sedation and increase cardiovascular depression perioperatively.
How serious is the interaction between Etomidate and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of loxapine use and titrate etomidate to effect. Monitor blood pressure and airway closely during induction and recovery.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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