Drug interactions
Etomidate + Metaxalone
Severity: Moderate
Etomidate and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and residual metaxalone may add to sedation and CNS depression. The practical effect is generally manageable in a monitored anesthetic setting.
What this interaction means in plain words
Etomidate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression through GABA-A modulation by etomidate and the sedating effect of metaxalone.
What to do
Tell the anesthesia team about recent metaxalone use and titrate induction and sedative doses to effect with standard monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Metaxalone?
MediHelp rates the interaction as moderate. Etomidate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and residual metaxalone may add to sedation and CNS depression. The practical effect is generally manageable in a monitored anesthetic setting.
How serious is the interaction between Etomidate and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent metaxalone use and titrate induction and sedative doses to effect with standard monitoring.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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