Drug interactions
Etomidate + Orphenadrin
Severity: Moderate
Etomidate and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has sedative and central anticholinergic properties that can add to the hypnotic effect of etomidate. This may deepen or prolong sedation and delay recovery after anesthesia.
What this interaction means in plain words
Etomidate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Monitor sedation depth and recovery time, and reduce etomidate or other sedative doses if the patient has recently taken orphenadrine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Orphenadrin?
MediHelp rates the interaction as moderate. Etomidate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has sedative and central anticholinergic properties that can add to the hypnotic effect of etomidate. This may deepen or prolong sedation and delay recovery after anesthesia.
How serious is the interaction between Etomidate and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation depth and recovery time, and reduce etomidate or other sedative doses if the patient has recently taken orphenadrine.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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