Drug interactions
Etomidate + Oxymorphone
Severity: Moderate
Etomidate and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous hypnotic used for anesthesia induction, and opioids add to its sedative and respiratory depressant effects. This is usually anticipated in anesthetic practice but may cause deeper sedation, apnea and hypotension.
What this interaction means in plain words
Etomidate and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression through GABA-A potentiation by etomidate and mu-opioid agonism by oxymorphone.
What to do
Use only where airway management and monitoring are available, and reduce the doses of the induction or sedative agents according to response. Monitor respiration and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Oxymorphone?
MediHelp rates the interaction as moderate. Etomidate and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous hypnotic used for anesthesia induction, and opioids add to its sedative and respiratory depressant effects. This is usually anticipated in anesthetic practice but may cause deeper sedation, apnea and hypotension.
How serious is the interaction between Etomidate and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway management and monitoring are available, and reduce the doses of the induction or sedative agents according to response. Monitor respiration and blood pressure continuously.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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