Drug interactions
Etomidate + Tranylcypromine
Severity: Moderate
Etomidate and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may alter anesthetic requirements and hemodynamic responses, and etomidate adds sedative-hypnotic effects. Clinically relevant interaction is uncertain but anesthetic effect or blood pressure changes could be altered.
What this interaction means in plain words
Etomidate and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive CNS depression and altered hemodynamic responses; the mechanism is not well established.
What to do
Inform the anesthesia team of MAO inhibitor use and titrate etomidate to effect with continuous hemodynamic monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Tranylcypromine?
MediHelp rates the interaction as moderate. Etomidate and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may alter anesthetic requirements and hemodynamic responses, and etomidate adds sedative-hypnotic effects. Clinically relevant interaction is uncertain but anesthetic effect or blood pressure changes could be altered.
How serious is the interaction between Etomidate and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of MAO inhibitor use and titrate etomidate to effect with continuous hemodynamic monitoring.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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