Drug interactions
Etonogestrel + Lapatinib
Severity: Minor
Etonogestrel and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib weakly inhibits CYP3A4 and might slightly increase etonogestrel levels. A clinically significant effect is unlikely.
What this interaction means in plain words
Etonogestrel and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4, which may modestly reduce etonogestrel metabolism.
What to do
No dose adjustment is needed. Be aware of possible increased progestogenic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Etonogestrel with Lapatinib?
MediHelp rates the interaction as minor. Etonogestrel and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib weakly inhibits CYP3A4 and might slightly increase etonogestrel levels. A clinically significant effect is unlikely.
How serious is the interaction between Etonogestrel and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of possible increased progestogenic effects.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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