Drug interactions
Etonogestrel + Ritonavir
Severity: Moderate
Etonogestrel and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 but also induces other enzymes, so hormonal contraceptive exposure may change unpredictably. Efficacy or progestin adverse effects may be affected.
What this interaction means in plain words
Etonogestrel and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 while inducing other metabolic pathways, giving variable effects on etonogestrel exposure.
What to do
Add a barrier method or use an alternative such as a copper IUD or DMPA. Monitor for progestin adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Etonogestrel with Ritonavir?
MediHelp rates the interaction as moderate. Etonogestrel and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 but also induces other enzymes, so hormonal contraceptive exposure may change unpredictably. Efficacy or progestin adverse effects may be affected.
How serious is the interaction between Etonogestrel and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a barrier method or use an alternative such as a copper IUD or DMPA. Monitor for progestin adverse effects.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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