Drug interactions
Etonogestrel + Verapamil
Severity: Minor
Etonogestrel and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etonogestrel is metabolized by CYP3A4, so verapamil may modestly increase its concentrations. This is unlikely to reduce contraceptive efficacy and is mainly a possible increase in progestogenic adverse effects.
What this interaction means in plain words
Etonogestrel and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 metabolism of etonogestrel.
What to do
No dose adjustment is generally needed. Counsel the patient to report bleeding changes or other progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Verapamil?
MediHelp rates the interaction as minor. Etonogestrel and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etonogestrel is metabolized by CYP3A4, so verapamil may modestly increase its concentrations. This is unlikely to reduce contraceptive efficacy and is mainly a possible increase in progestogenic adverse effects.
How serious is the interaction between Etonogestrel and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Counsel the patient to report bleeding changes or other progestogenic adverse effects.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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