Drug interactions
Etonogestrel + Zafirlukast
Severity: Minor
Etonogestrel and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etonogestrel is metabolized by CYP3A4, so inhibitors may raise its concentration slightly. With zafirlukast's weak inhibition, contraceptive efficacy is not expected to be affected and the change is unlikely to matter.
What this interaction means in plain words
Etonogestrel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may modestly reduce etonogestrel clearance.
What to do
No action is needed beyond awareness. Monitor for progestogen-related adverse effects such as bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Zafirlukast?
MediHelp rates the interaction as minor. Etonogestrel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etonogestrel is metabolized by CYP3A4, so inhibitors may raise its concentration slightly. With zafirlukast's weak inhibition, contraceptive efficacy is not expected to be affected and the change is unlikely to matter.
How serious is the interaction between Etonogestrel and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. Monitor for progestogen-related adverse effects such as bleeding changes.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
Full monographs, dosing and an interaction checker in the MediHelp app
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