Drug interactions
Etrasimod + Everolimus
Severity: Major
Etrasimod and Everolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is an S1P receptor modulator that lowers circulating lymphocytes, and everolimus is an immunosuppressant. Together they may increase the risk of infection, and the effect persists for weeks after etrasimod is stopped.
What this interaction means in plain words
Etrasimod and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Everolimus belongs to Oncology.
Why it happens
Additive immunosuppression from lymphocyte sequestration and mTOR inhibition.
What to do
Avoid the combination where possible, and monitor for infection and lymphocyte counts if both are required, remembering the prolonged pharmacodynamic effect after etrasimod is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Everolimus?
MediHelp rates the interaction as major. Etrasimod and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is an S1P receptor modulator that lowers circulating lymphocytes, and everolimus is an immunosuppressant. Together they may increase the risk of infection, and the effect persists for weeks after etrasimod is stopped.
How serious is the interaction between Etrasimod and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and monitor for infection and lymphocyte counts if both are required, remembering the prolonged pharmacodynamic effect after etrasimod is stopped.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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