Drug interactions
Etrasimod + Fluconazole
Severity: Major
Etrasimod and Fluconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits both CYP2C9 and CYP3A4, key pathways for etrasimod, and may increase its exposure. This could heighten bradycardia, atrioventricular conduction effects and other adverse reactions.
What this interaction means in plain words
Etrasimod and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Combined CYP2C9 and CYP3A4 inhibition by fluconazole reducing etrasimod clearance.
What to do
Avoid concurrent use; choose an alternative antifungal. If unavoidable, monitor heart rate and ECG and watch for etrasimod adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Fluconazole?
MediHelp rates the interaction as major. Etrasimod and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole inhibits both CYP2C9 and CYP3A4, key pathways for etrasimod, and may increase its exposure. This could heighten bradycardia, atrioventricular conduction effects and other adverse reactions.
How serious is the interaction between Etrasimod and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative antifungal. If unavoidable, monitor heart rate and ECG and watch for etrasimod adverse effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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