Drug interactions
Etrasimod + Hydrochlorothiazide-irbesartan
Severity: Minor
Etrasimod and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod exposure rises when moderate to strong CYP2C8 inhibitors are combined with CYP2C9 poor metabolizer status. Irbesartan is not an established CYP2C8 inhibitor, so a meaningful interaction is unlikely.
What this interaction means in plain words
Etrasimod and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Theoretical effect on etrasimod metabolism via CYP2C8/CYP2C9; irbesartan has no established inhibitory activity.
What to do
No adjustment needed; monitor heart rate and routine etrasimod safety parameters.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Etrasimod and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod exposure rises when moderate to strong CYP2C8 inhibitors are combined with CYP2C9 poor metabolizer status. Irbesartan is not an established CYP2C8 inhibitor, so a meaningful interaction is unlikely.
How serious is the interaction between Etrasimod and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor heart rate and routine etrasimod safety parameters.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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