Drug interactions
Etrasimod + Hydroxychloroquine
Severity: Moderate
Etrasimod and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is a sphingosine 1-phosphate receptor modulator that can cause bradycardia and atrioventricular conduction delay, and hydroxychloroquine can prolong the QT interval. Bradycardia combined with QT prolongation increases the risk of torsades de pointes.
What this interaction means in plain words
Etrasimod and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Pharmacodynamic: S1P-mediated bradycardia combined with hydroxychloroquine-related QT prolongation increases arrhythmic risk.
What to do
Obtain a baseline ECG before starting etrasimod and monitor heart rate and QTc in patients on hydroxychloroquine. Seek cardiology advice for patients with pre-existing QT prolongation or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Etrasimod and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod is a sphingosine 1-phosphate receptor modulator that can cause bradycardia and atrioventricular conduction delay, and hydroxychloroquine can prolong the QT interval. Bradycardia combined with QT prolongation increases the risk of torsades de pointes.
How serious is the interaction between Etrasimod and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and monitor heart rate and QTc in patients on hydroxychloroquine. Seek cardiology advice for patients with pre-existing QT prolongation or conduction disease.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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