Drug interactions
Etrasimod + Infliximab
Severity: Major
Etrasimod and Infliximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes through S1P receptor modulation, and combining it with infliximab may add to immunosuppression and infection risk. The combination has not been well studied, and the effect persists for some time after etrasimod is stopped.
What this interaction means in plain words
Etrasimod and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Infliximab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from lymphocyte sequestration by S1P modulation and TNF blockade.
What to do
Avoid concurrent use where possible, including in the weeks after etrasimod discontinuation. If combined, monitor for infection and lymphocyte count.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Infliximab?
MediHelp rates the interaction as major. Etrasimod and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes through S1P receptor modulation, and combining it with infliximab may add to immunosuppression and infection risk. The combination has not been well studied, and the effect persists for some time after etrasimod is stopped.
How serious is the interaction between Etrasimod and Infliximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, including in the weeks after etrasimod discontinuation. If combined, monitor for infection and lymphocyte count.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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