Drug interactions
Etrasimod + Ruxolitinib
Severity: Major
Etrasimod and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have immunosuppressive effects, so combining them may increase the risk of infection. Etrasimod lowers circulating lymphocytes and the effect persists for some weeks after stopping. The combination has not been formally studied.
What this interaction means in plain words
Etrasimod and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Ruxolitinib belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation and JAK inhibition.
What to do
Avoid combining them if possible. If used together, monitor for infection and lymphocyte and neutrophil counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Ruxolitinib?
MediHelp rates the interaction as major. Etrasimod and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have immunosuppressive effects, so combining them may increase the risk of infection. Etrasimod lowers circulating lymphocytes and the effect persists for some weeks after stopping. The combination has not been formally studied.
How serious is the interaction between Etrasimod and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them if possible. If used together, monitor for infection and lymphocyte and neutrophil counts.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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