Drug interactions
Etrasimod + Temozolomide
Severity: Moderate
Etrasimod and Temozolomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and temozolomide is myelosuppressive and lymphopenic. Together they may add to immunosuppression and infection risk, and the combination has not been formally studied.
What this interaction means in plain words
Etrasimod and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Temozolomide belongs to Oncology.
Why it happens
Additive pharmacodynamic immunosuppression: S1P receptor modulation sequesters lymphocytes while temozolomide depletes marrow and lymphocyte populations.
What to do
Avoid the combination where possible. If both are needed, monitor complete blood count including lymphocytes and watch for infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temozolomide
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Temozolomide?
MediHelp rates the interaction as moderate. Etrasimod and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod reduces circulating lymphocytes, and temozolomide is myelosuppressive and lymphopenic. Together they may add to immunosuppression and infection risk, and the combination has not been formally studied.
How serious is the interaction between Etrasimod and Temozolomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor complete blood count including lymphocytes and watch for infections.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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