Drug interactions
Etrasimod + Vedolizumab
Severity: Moderate
Etrasimod and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and has not been studied with other immunomodulators, so adding vedolizumab may increase infection risk. Vedolizumab's gut-selective action limits but does not remove this concern, and etrasimod's effects persist for weeks after stopping.
What this interaction means in plain words
Etrasimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immune effects from S1P receptor modulation (lymphocyte sequestration) and gut-selective integrin blockade.
What to do
Avoid routine coadministration and monitor lymphocyte counts and signs of infection if the combination is used. Allow for the persistent effect of etrasimod when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Vedolizumab?
MediHelp rates the interaction as moderate. Etrasimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocytes and has not been studied with other immunomodulators, so adding vedolizumab may increase infection risk. Vedolizumab's gut-selective action limits but does not remove this concern, and etrasimod's effects persist for weeks after stopping.
How serious is the interaction between Etrasimod and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration and monitor lymphocyte counts and signs of infection if the combination is used. Allow for the persistent effect of etrasimod when switching therapies.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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