Drug interactions
Etravirine + Fluoxetine
Severity: Minor
Etravirine and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is metabolised by CYP3A4, CYP2C9 and CYP2C19, and fluoxetine can inhibit CYP2C19 and CYP2C9. Etravirine concentrations may rise modestly. Clinical consequences are generally limited given etravirine's wide tolerability.
What this interaction means in plain words
Etravirine and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine inhibits CYP2C9/2C19, which may reduce etravirine clearance.
What to do
No dose change is usually needed; monitor for etravirine adverse effects such as rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Fluoxetine?
MediHelp rates the interaction as minor. Etravirine and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is metabolised by CYP3A4, CYP2C9 and CYP2C19, and fluoxetine can inhibit CYP2C19 and CYP2C9. Etravirine concentrations may rise modestly. Clinical consequences are generally limited given etravirine's wide tolerability.
How serious is the interaction between Etravirine and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for etravirine adverse effects such as rash.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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