Drug interactions
Etravirine + Hydrocodone
Severity: Moderate
Etravirine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower hydrocodone concentrations, reducing analgesia. Stopping etravirine could cause hydrocodone levels to rise and lead to respiratory depression.
What this interaction means in plain words
Etravirine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Hydrocodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 increasing hydrocodone metabolism.
What to do
Monitor pain control and titrate hydrocodone. Reduce the dose and monitor for sedation and respiratory depression if etravirine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Hydrocodone?
MediHelp rates the interaction as moderate. Etravirine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower hydrocodone concentrations, reducing analgesia. Stopping etravirine could cause hydrocodone levels to rise and lead to respiratory depression.
How serious is the interaction between Etravirine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate hydrocodone. Reduce the dose and monitor for sedation and respiratory depression if etravirine is withdrawn.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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