Drug interactions
Etravirine + Imatinib
Severity: Moderate
Etravirine and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may inhibit CYP2C9 and CYP2C19 and could increase etravirine concentrations. Etravirine is generally well tolerated, so the effect is expected to be modest, though rash is possible. Etravirine as a CYP3A4 inducer could also lower imatinib levels.
What this interaction means in plain words
Etravirine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Imatinib belongs to Oncology.
Why it happens
Imatinib may inhibit CYP2C9/2C19 metabolism of etravirine, while etravirine may induce CYP3A4 and reduce imatinib exposure.
What to do
Monitor for etravirine adverse effects such as rash and for reduced imatinib response; consider therapeutic drug monitoring of imatinib if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Imatinib?
MediHelp rates the interaction as moderate. Etravirine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may inhibit CYP2C9 and CYP2C19 and could increase etravirine concentrations. Etravirine is generally well tolerated, so the effect is expected to be modest, though rash is possible. Etravirine as a CYP3A4 inducer could also lower imatinib levels.
How serious is the interaction between Etravirine and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for etravirine adverse effects such as rash and for reduced imatinib response; consider therapeutic drug monitoring of imatinib if available.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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