Drug interactions
Etravirine + Lapatinib
Severity: Moderate
Etravirine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower lapatinib exposure, reducing efficacy. Lapatinib may in turn raise etravirine levels through CYP3A4 inhibition, though the effect is likely modest.
What this interaction means in plain words
Etravirine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Lapatinib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4 and lapatinib inhibits CYP3A4, altering clearance of each other.
What to do
Monitor for reduced lapatinib response and consider a dose increase if an inducer is unavoidable. Monitor antiretroviral efficacy and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Lapatinib?
MediHelp rates the interaction as moderate. Etravirine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower lapatinib exposure, reducing efficacy. Lapatinib may in turn raise etravirine levels through CYP3A4 inhibition, though the effect is likely modest.
How serious is the interaction between Etravirine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced lapatinib response and consider a dose increase if an inducer is unavoidable. Monitor antiretroviral efficacy and tolerability.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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