Drug interactions
Etravirine + Nicardipine
Severity: Moderate
Etravirine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower nicardipine concentrations, diminishing blood pressure control. Etravirine is also a weak CYP2C9 and CYP2C19 inhibitor, which is not relevant to nicardipine.
What this interaction means in plain words
Etravirine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Etravirine induces CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure and titrate nicardipine to effect after etravirine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Nicardipine?
MediHelp rates the interaction as moderate. Etravirine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower nicardipine concentrations, diminishing blood pressure control. Etravirine is also a weak CYP2C9 and CYP2C19 inhibitor, which is not relevant to nicardipine.
How serious is the interaction between Etravirine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine to effect after etravirine is started or stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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