Drug interactions
Etravirine + Prednisone
Severity: Moderate
Etravirine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower prednisolone exposure, potentially reducing anti-inflammatory effect. Systemic corticosteroids may also modestly lower etravirine levels, though this is less well documented.
What this interaction means in plain words
Etravirine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Prednisone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4, increasing prednisolone clearance.
What to do
Monitor clinical response to prednisone and increase the dose if the effect is lost. Monitor HIV viral load for loss of antiviral control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Prednisone?
MediHelp rates the interaction as moderate. Etravirine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower prednisolone exposure, potentially reducing anti-inflammatory effect. Systemic corticosteroids may also modestly lower etravirine levels, though this is less well documented.
How serious is the interaction between Etravirine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to prednisone and increase the dose if the effect is lost. Monitor HIV viral load for loss of antiviral control.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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