Drug interactions
Etravirine + Primaquine
Severity: Moderate
Etravirine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a weak to moderate CYP3A4 inducer and may lower primaquine concentrations. Reduced exposure could weaken efficacy, though primaquine's active metabolites are complex and the clinical impact is uncertain.
What this interaction means in plain words
Etravirine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Primaquine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4-mediated metabolism by etravirine.
What to do
Monitor for reduced antimalarial response or relapse. Consider whether primaquine dose adjustment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Primaquine?
MediHelp rates the interaction as moderate. Etravirine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a weak to moderate CYP3A4 inducer and may lower primaquine concentrations. Reduced exposure could weaken efficacy, though primaquine's active metabolites are complex and the clinical impact is uncertain.
How serious is the interaction between Etravirine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimalarial response or relapse. Consider whether primaquine dose adjustment is needed.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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