Drug interactions
Etravirine + Propafenone
Severity: Moderate
Etravirine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower propafenone concentrations, possibly reducing antiarrhythmic control. Etravirine also inhibits CYP2C9 and CYP2C19, but no clear effect on propafenone clinical outcomes is documented.
What this interaction means in plain words
Etravirine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Propafenone belongs to Cardiovascular.
Why it happens
Induction of CYP3A4-mediated propafenone metabolism.
What to do
Monitor for loss of arrhythmia control and ECG changes after starting etravirine. Adjust the propafenone dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Propafenone?
MediHelp rates the interaction as moderate. Etravirine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower propafenone concentrations, possibly reducing antiarrhythmic control. Etravirine also inhibits CYP2C9 and CYP2C19, but no clear effect on propafenone clinical outcomes is documented.
How serious is the interaction between Etravirine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of arrhythmia control and ECG changes after starting etravirine. Adjust the propafenone dose based on response.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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