Drug interactions
Etravirine + Ramelteon
Severity: Minor
Etravirine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a weak CYP3A4 inducer and a CYP2C9/2C19 inhibitor, so its net effect on ramelteon is unpredictable. Any change in ramelteon exposure is probably small, but efficacy could be reduced or sedation increased.
What this interaction means in plain words
Etravirine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Ramelteon belongs to Central Nervous System.
Why it happens
Opposing effects on CYP3A4 induction and CYP2C9 inhibition alter ramelteon metabolism in an unpredictable way.
What to do
No empirical dose change is needed; adjust based on clinical response for insomnia and daytime sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ramelteon?
MediHelp rates the interaction as minor. Etravirine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a weak CYP3A4 inducer and a CYP2C9/2C19 inhibitor, so its net effect on ramelteon is unpredictable. Any change in ramelteon exposure is probably small, but efficacy could be reduced or sedation increased.
How serious is the interaction between Etravirine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; adjust based on clinical response for insomnia and daytime sedation.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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