Drug interactions
Etravirine + Regorafenib
Severity: Moderate
Etravirine and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may reduce regorafenib exposure, potentially compromising efficacy, while raising levels of the M-5 metabolite.
What this interaction means in plain words
Etravirine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Regorafenib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4, increasing regorafenib clearance.
What to do
Avoid if feasible or monitor for reduced tumor response and toxicity. Consider an alternative antiretroviral.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Regorafenib?
MediHelp rates the interaction as moderate. Etravirine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may reduce regorafenib exposure, potentially compromising efficacy, while raising levels of the M-5 metabolite.
How serious is the interaction between Etravirine and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible or monitor for reduced tumor response and toxicity. Consider an alternative antiretroviral.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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