Drug interactions
Etravirine + Ritonavir
Severity: Moderate
Etravirine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir at full dose reduces etravirine exposure, and the combination is not recommended at 600 mg twice daily. Low-dose ritonavir as a booster of other protease inhibitors is acceptable and counters etravirine inducing effects.
What this interaction means in plain words
Etravirine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir induces CYP enzymes on repeated dosing, lowering etravirine exposure, while etravirine induces CYP3A4.
What to do
Avoid full-dose ritonavir with etravirine. Use only low-dose ritonavir as a booster of a compatible protease inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Etravirine with Ritonavir?
MediHelp rates the interaction as moderate. Etravirine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir at full dose reduces etravirine exposure, and the combination is not recommended at 600 mg twice daily. Low-dose ritonavir as a booster of other protease inhibitors is acceptable and counters etravirine inducing effects.
How serious is the interaction between Etravirine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid full-dose ritonavir with etravirine. Use only low-dose ritonavir as a booster of a compatible protease inhibitor.
What other medicines interact with Etravirine?
MediHelp also lists interactions of Etravirine with, for example, Efavirenz, Isavuconazole, Amobarbital. The full list is on the Etravirine page.
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