Drug interactions
Etravirine + Ticagrelor
Severity: Moderate
Etravirine and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower ticagrelor and its active metabolite concentrations. Reduced exposure may weaken platelet inhibition and raise the risk of stent thrombosis or ischemic events.
What this interaction means in plain words
Etravirine and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ticagrelor belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by etravirine increasing ticagrelor clearance.
What to do
Monitor for loss of antiplatelet efficacy and consider an alternative antiplatelet agent if a prolonged course is needed. Coordinate with the HIV team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ticagrelor?
MediHelp rates the interaction as moderate. Etravirine and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower ticagrelor and its active metabolite concentrations. Reduced exposure may weaken platelet inhibition and raise the risk of stent thrombosis or ischemic events.
How serious is the interaction between Etravirine and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antiplatelet efficacy and consider an alternative antiplatelet agent if a prolonged course is needed. Coordinate with the HIV team.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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