Drug interactions
Etravirine + Tinidazole
Severity: Moderate
Etravirine and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower tinidazole concentrations. Reduced exposure could compromise treatment of infections such as trichomoniasis or giardiasis.
What this interaction means in plain words
Etravirine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by etravirine increases tinidazole clearance.
What to do
Monitor clinical response to tinidazole and consider extending therapy or an alternative if treatment fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Tinidazole?
MediHelp rates the interaction as moderate. Etravirine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower tinidazole concentrations. Reduced exposure could compromise treatment of infections such as trichomoniasis or giardiasis.
How serious is the interaction between Etravirine and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole and consider extending therapy or an alternative if treatment fails.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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