Drug interactions
Etravirine + Tolbutamide
Severity: Minor
Etravirine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and may raise exposure to CYP2C9 substrates such as tolbutamide. This could enhance the glucose-lowering effect, although etravirine also induces some enzymes, so the net effect is uncertain.
What this interaction means in plain words
Etravirine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Tolbutamide belongs to Endocrine.
Why it happens
Etravirine inhibition of CYP2C9 may reduce tolbutamide clearance.
What to do
Monitor blood glucose after starting etravirine and reduce the tolbutamide dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Tolbutamide?
MediHelp rates the interaction as minor. Etravirine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine inhibits CYP2C9 and may raise exposure to CYP2C9 substrates such as tolbutamide. This could enhance the glucose-lowering effect, although etravirine also induces some enzymes, so the net effect is uncertain.
How serious is the interaction between Etravirine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting etravirine and reduce the tolbutamide dose if hypoglycemia develops.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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