Drug interactions
Etravirine + Verapamil
Severity: Moderate
Etravirine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine may lower verapamil concentrations through CYP3A4 induction, reducing its effect, while verapamil may modestly raise etravirine levels. The net effect is variable.
What this interaction means in plain words
Etravirine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Verapamil belongs to Cardiovascular.
Why it happens
Etravirine induces CYP3A4 while verapamil inhibits CYP3A4 and P-glycoprotein.
What to do
Monitor blood pressure, heart rate and symptom control, and titrate verapamil to effect. No etravirine adjustment is usually needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Verapamil?
MediHelp rates the interaction as moderate. Etravirine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine may lower verapamil concentrations through CYP3A4 induction, reducing its effect, while verapamil may modestly raise etravirine levels. The net effect is variable.
How serious is the interaction between Etravirine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptom control, and titrate verapamil to effect. No etravirine adjustment is usually needed.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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