Drug interactions
Etravirine + Vinblastine
Severity: Moderate
Etravirine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower vinblastine exposure. This could reduce antineoplastic efficacy, though clinical data are limited.
What this interaction means in plain words
Etravirine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Vinblastine belongs to Oncology.
Why it happens
Etravirine induces CYP3A4, increasing vinblastine clearance.
What to do
Monitor tumor response and consider an alternative antiretroviral without enzyme induction if response seems inadequate. Coordinate with the HIV specialist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Vinblastine?
MediHelp rates the interaction as moderate. Etravirine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower vinblastine exposure. This could reduce antineoplastic efficacy, though clinical data are limited.
How serious is the interaction between Etravirine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an alternative antiretroviral without enzyme induction if response seems inadequate. Coordinate with the HIV specialist.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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