Drug interactions
Etravirine + Zafirlukast
Severity: Minor
Etravirine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP2C9 and weakly CYP3A4, both involved in etravirine metabolism, so etravirine levels may increase. Etravirine has a wide safety margin, so the effect is generally tolerable.
What this interaction means in plain words
Etravirine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP2C9 and CYP3A4 by zafirlukast reduces etravirine clearance.
What to do
No dose adjustment is generally needed; monitor for rash and other etravirine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Zafirlukast?
MediHelp rates the interaction as minor. Etravirine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP2C9 and weakly CYP3A4, both involved in etravirine metabolism, so etravirine levels may increase. Etravirine has a wide safety margin, so the effect is generally tolerable.
How serious is the interaction between Etravirine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for rash and other etravirine adverse effects.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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