Drug interactions
Everolimus + Givinostat
Severity: Minor
Everolimus and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat weakly inhibits CYP3A4 and may modestly increase exposure to everolimus. The effect is likely small but everolimus has a narrow therapeutic window.
What this interaction means in plain words
Everolimus and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Givinostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by givinostat reduces the metabolism of everolimus.
What to do
Monitor everolimus trough levels and tolerability when givinostat is started or stopped. Adjust the everolimus dose only if levels or toxicity warrant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Everolimus with Givinostat?
MediHelp rates the interaction as minor. Everolimus and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat weakly inhibits CYP3A4 and may modestly increase exposure to everolimus. The effect is likely small but everolimus has a narrow therapeutic window.
How serious is the interaction between Everolimus and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and tolerability when givinostat is started or stopped. Adjust the everolimus dose only if levels or toxicity warrant.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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