Drug interactions
Everolimus + Istradefylline
Severity: Moderate
Everolimus and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline increases exposure to CYP3A4 and P-gp substrates and may raise everolimus levels. This could increase everolimus toxicity, whereas the 20 mg dose appears to have little effect.
What this interaction means in plain words
Everolimus and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 and P-glycoprotein, reducing everolimus clearance and increasing absorption.
What to do
Monitor everolimus trough levels and toxicity, and reduce the everolimus dose if levels are high, particularly with istradefylline 40 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Everolimus with Istradefylline?
MediHelp rates the interaction as moderate. Everolimus and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline increases exposure to CYP3A4 and P-gp substrates and may raise everolimus levels. This could increase everolimus toxicity, whereas the 20 mg dose appears to have little effect.
How serious is the interaction between Everolimus and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and toxicity, and reduce the everolimus dose if levels are high, particularly with istradefylline 40 mg daily.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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