Drug interactions
Everolimus + Moexipril
Severity: Major
Everolimus and Moexipril: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors such as everolimus are associated with angioedema, and the risk is higher when taken with ACE inhibitors. Swelling of the face, lips, tongue or airway may occur.
What this interaction means in plain words
Everolimus and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Moexipril belongs to Cardiovascular.
Why it happens
Likely additive impairment of bradykinin breakdown: ACE inhibition raises bradykinin and mTOR inhibitors may further contribute to angioedema.
What to do
Prefer an alternative antihypertensive class where possible. If combined, counsel patients to seek urgent care for swelling and stop the drugs if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Everolimus and Moexipril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Moexipril?
MediHelp rates the interaction as major. Everolimus and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. mTOR inhibitors such as everolimus are associated with angioedema, and the risk is higher when taken with ACE inhibitors. Swelling of the face, lips, tongue or airway may occur.
How serious is the interaction between Everolimus and Moexipril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antihypertensive class where possible. If combined, counsel patients to seek urgent care for swelling and stop the drugs if angioedema occurs.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
