Drug interactions
Everolimus + Pitolisant
Severity: Minor
Everolimus and Pitolisant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is a weak CYP3A4 inducer and may lower everolimus concentrations slightly. This may reduce efficacy.
What this interaction means in plain words
Everolimus and Pitolisant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Pitolisant belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases everolimus metabolism.
What to do
Monitor everolimus trough concentrations and response, and increase the dose if levels are subtherapeutic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Everolimus with Pitolisant?
MediHelp rates the interaction as minor. Everolimus and Pitolisant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pitolisant is a weak CYP3A4 inducer and may lower everolimus concentrations slightly. This may reduce efficacy.
How serious is the interaction between Everolimus and Pitolisant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and response, and increase the dose if levels are subtherapeutic.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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